Pharmacological progresses of puerarin in the prevention and treatment of atherosclerosis
By: Jia, Liyi
.
Contributor(s): Xing, Lu.
Publisher: Mumbai Indian Journal of Pharmaceutical Science 2023Edition: Vol.85(4), Jul-Aug.Description: 884-894p.Subject(s): PHARMACEUTICSOnline resources: Click here
In:
Indian journal of pharmaceutical sciencesSummary: Atherosclerosis is an independent risk factor for cardiovascular diseases, which is related to dyslipidemia,
endothelial injury, inflammation, thrombosis, dysfunction of vascular smooth muscle cells and macrophages,
etc. Puerarin, a natural monomer from Chinese herb Pueraria lobata, presents multiple cardiovascular
protective activities. The paper firstly reviewed the risk factors and drug of atherosclerosis. And then,
extraction and synthesis of puerarin were summarized. Especially, it focused on the latest advances in
anti-atherosclerosis activities of puerarin from six aspects including lipid-regulating, hyperglycemic, anti-
inflammatory, inhibiting thrombosis, promoting microcirculation, improving functions of vascular smooth
muscle cells and macrophages. Some novel puerarin derivatives also exhibited favorable anti-atherosclerosis
activity. The review would provide new molecular skeletons and lead compounds for anti-atherosclerosis new
drug development based on puerarin.
| Item type | Current location | Call number | Status | Date due | Barcode | Item holds |
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Articles Abstract Database
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School of Pharmacy Archieval Section | Not for loan | 2024-0398 |
Atherosclerosis is an independent risk factor for cardiovascular diseases, which is related to dyslipidemia,
endothelial injury, inflammation, thrombosis, dysfunction of vascular smooth muscle cells and macrophages,
etc. Puerarin, a natural monomer from Chinese herb Pueraria lobata, presents multiple cardiovascular
protective activities. The paper firstly reviewed the risk factors and drug of atherosclerosis. And then,
extraction and synthesis of puerarin were summarized. Especially, it focused on the latest advances in
anti-atherosclerosis activities of puerarin from six aspects including lipid-regulating, hyperglycemic, anti-
inflammatory, inhibiting thrombosis, promoting microcirculation, improving functions of vascular smooth
muscle cells and macrophages. Some novel puerarin derivatives also exhibited favorable anti-atherosclerosis
activity. The review would provide new molecular skeletons and lead compounds for anti-atherosclerosis new
drug development based on puerarin.
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